The natural variability of botanical material often makes it difficult to ensure a consistent quality process for pharmaceuticals made from plant-based products. In addition, botanical drug products (BDPs) are often produced using a series of separate batch processes, which adds even more variability into the manufacturing process.
Many elderly people are afraid of falling – and for good reasons. Falls can have serious consequences for the individual but also the fear of falling could have serious effects on health and independence. A new research project at Luleå University of Technology in Sweden has taken a closer look at fall-related concerns among elderly people, using multivariate data analysis, MVDA, with the ultimate goal of finding diagnostic and training methods that could help reduce falls. Results from the first studies have given some interesting answers.
What’s the secret formula for creating long-lasting bubbles? Is expert knowledge of liquid dynamics needed to optimize the mixture design and develop the best bubble solution? Or can we use design of experiments (DOE) and data analytics to draw conclusions? Let’s a take a look at a fun example of how DOE can be used to optimize a mixture design in order to achieve our goal: create long-lasting bubbles.
Advancements in cell and gene therapy hold promise for the future of personalized medicine, especially for cancer treatments. However, bioprocessing methods for autologous cellular therapies, and CAR-T in particular, often present unique challenges in manufacturing due to the variability of the starting material and unique nature of each batch. Is there a way to create more efficient processes in order to bring down costs and make personalized medicine a viable option for more patients?
Could data analytics aid in the diagnosis of severe neurological diseases? In a recent study, a research group at Umeå University has conducted statistical data analysis of biomarkers from patients suffering from Amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease) and Parkinson’s disease to investigate whether data analytics could help in the diagnosis of – and help distinguish between – the two diseases.
Pressure to cut development costs and lower regulatory barriers while assuring product quality has stimulated the pharmaceutical industry to apply Quality by Design (QbD) to manage risk and gain process and product understanding. As a result, QbD is being widely promoted by regulatory authorities such as the Food and Drug Administration, and the International Conference on Harmonization.
Mining information in unstructured text can be a real challenge. Patent documents, for example, provide a rich source of technological and scientific knowledge that can reveal technological trends as well as information on the legal landscape of the market. This makes analysis of the vast and ever-growing number of patents an important part of corporate business strategies.
Making the perfect bar of chocolate is not just about mixing the right amount of sugar and cocoa, or adjusting the process for product quality. Another factor that must be taken into account to optimize both taste and profits is the grinding time of the cocoa beans. Let’s take a look at how data analytics can be used to elevate both, and to find the right combination of ingredients and process to support the business goals — an important factor in the food and beverage industry.
Making sure your data and processes from research and development through to production are compliant is essential in today's highly regulated life science, biopharma, pharmaceutical and food industries. But it's no easy task. Following all of the required steps and ensuring the integrity of your data at every stage is easier and more successful when you use a product designed to keep your data compliant.
On the west coast of southern Sweden, facing the expanse of the ocean, is the beautiful city of Gothenburg. Surrounded by a string of islands, this city has been the home for sailors and merchants, seafaring and shipping, since ancient times. One of the islands to the north of Gothenburg is the picturesque island of Tjörn. Once every year, Tjörn is the location for one of the most famous sailing races in Sweden – “Tjörn Runt” or “Around Tjörn”.